Isogenic and allogenic transplatation of isolated langerhans islets into the liver

This preliminary experimental report confirms the previous interest of isolated endocrine islet transplantation. Moreover a new "privileged position" for the islets grafts is proposed and is as uneventful as a liver biopsy. The functional value of this grafting procedure has been assessed on biological and functional criteria. The transplanted islets are easily retrievable and histological and especially immunocytochemical studies demonstrate the morphological behaviour of such islets. Finally the preliminary survival of allogeneic grafts into the liver supports the concept of the role of the liver during enhancement of facilitation and will be the subject of further investigations.