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Serotonin receptor subtypes and affective disorders
1Central Nervous System Clinical Research, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492-7660.
Clinical Neuropharmacology
|January 1, 1993
Abstract:
The role of drugs that act at 5-hydroxytryptamine (5-HT or serotonin) receptor subtypes in the etiology and treatment of affective disorders is discussed. The mechanisms of action of drugs affecting 5-HT are described, with emphasis on those with anxiolytic and antidepressant activity. Evidence supporting a role for serotonin in the etiology and treatment of affective disorders in cited. Recent therapeutic advances have resulted in a new generation of serotonergic drugs.