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Related Experiment Videos

Minoxidil overdose

A R MacMillan1, F J Warshawski, R A Steinberg

  • 1Holy Cross Hospital-Calgary District Hospital Group, Alberta, Canada.

Chest
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Minoxidil topical solution ingestion can cause severe hypotension and tachycardia. Prompt resuscitation and vasopressor treatment are crucial for managing this toxicity and preventing cardiac complications.

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Area of Science:

  • Pharmacology
  • Toxicology
  • Cardiovascular Medicine

Background:

  • Topical minoxidil is widely used for hair regrowth.
  • Accidental or intentional ingestion can lead to systemic absorption.
  • Understanding minoxidil toxicity is crucial for emergency medicine.

Observation:

  • A 52-year-old man ingested 60 ml of 2% topical minoxidil solution.
  • The patient presented with severe hypotension and tachycardia.
  • Initial resuscitation included crystalloid solution and dopamine, yielding partial hemodynamic improvement.

Findings:

  • Intravenous phenylephrine infusion successfully resolved the hypotension.
  • The patient experienced a non-Q-wave myocardial infarction secondary to minoxidil toxicity.

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  • Minoxidil toxicity can have profound and severe cardiovascular effects.

    • Implications:

    • This case highlights the significant systemic toxicity of topical minoxidil upon ingestion.
    • Clinicians should be aware of the potential for severe hemodynamic compromise and myocardial injury.
    • Prompt and aggressive management with vasopressors is essential in minoxidil overdose cases.