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Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear
S Houldsworth1, P W Andrew, T J Mitchell
1Department of Microbiology and Immunology, University of Leicester, United Kingdom.
Infection and Immunity
|April 1, 1994
Abstract:
Human peripheral blood monocytes and a human monocyte cell line were exposed to the toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The viability of cells was not affected by the concentrations of pneumolysin used in the experiments.