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Effect of ceftibuten on the normal intestinal microflora
B Brismar1, C Edlund, C E Nord
1Dept. of Surgery, Karolinska Institute, Huddinge University Hospital, Sweden.
Infection
|November 1, 1993
Summary
Ceftibuten oral administration led to gut microbiota changes, including enterococci overgrowth and reduced E. coli. Clostridium difficile colonization and increased beta-lactamase activity were also observed in healthy volunteers.
Area of Science:
- Pharmacology
- Microbiology
- Gastroenterology
Background:
- Ceftibuten is a third-generation cephalosporin antibiotic.
- Understanding its impact on gut microbiota is crucial for clinical practice.
Purpose of the Study:
- To evaluate the effects of oral ceftibuten on the human gut microbiota composition and function.
Main Methods:
- 14 healthy volunteers received 400 mg ceftibuten daily for 10 days.
- Stool samples were analyzed before, during, and after treatment.
- Gut microbiota composition and beta-lactamase activity were assessed.
Main Results:
- Ceftibuten was well absorbed with minimal fecal excretion.
- Significant overgrowth of enterococci and reduction in Escherichia coli and anaerobic cocci were observed.
- Six volunteers were colonized by Clostridium difficile, and fecal beta-lactamase activity increased.
Conclusions:
- Oral ceftibuten significantly alters gut microbiota, promoting enterococci overgrowth and increasing C. difficile colonization risk.
- Increased fecal beta-lactamase activity suggests potential resistance mechanisms.
- Further research is needed to assess long-term implications.