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The effects of oxygenated free radicals on VEP spectral components in experimental diabetes
K C Apaydin1, A Ağar, P Yargiçoğlu
1Department of Ophthalmology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Abstract:
In this experimental research, 33 Swiss albino rats were studied. They were divided into three equal groups as control, alloxan-diabetic (diabetic group) and alloxan-diabetic rats treated with ginkgo biloba extract (diabetic-GbE group). After two months of diabetes and before ophthalmoscopically visible diabetic retinopathy, flash VEPs of three groups were recorded and spectral analysis of VEPs was computed by Fast Fourier Transform (FFT) algorithm. Comparing the results of diabetic and diabetic-GbE groups with control group, we observed a significant increase in the amplitude (dB) of 5 Hz frequency for the left and right responses of rats. At some frequencies, we also found important differences between diabetic-GbE and control groups.