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Signet-ring cell lymphoma of bone marrow
D C Talbot1, J H Davies, K A Maclennan
1ICRF Clinical Oncology Unit, Churchill Hospital, Headington, Oxford.
Journal of Clinical Pathology
|February 1, 1994
Summary
This report details a rare case of signet-ring cell lymphoma impacting bone marrow, presenting as spinal lesions. The patient successfully responded to chemotherapy, indicating treatment efficacy for this uncommon lymphoma subtype.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Signet-ring cell lymphoma is a rare morphologic variant of non-Hodgkin lymphoma.
- Bone marrow involvement by lymphoma can manifest in various ways, including lytic lesions.
Observation:
- A patient presented with multiple lytic lesions in the lumbosacral spine.
- Bone biopsy revealed characteristic signet-ring cell lymphoma morphology.
- Immunohistochemistry confirmed CD20 positivity in tumor cells.
Findings:
- The signet-ring cells, despite vacuolated cytoplasm, did not show intracellular immunoglobulin light or heavy chains.
- The lymphoma subtype was identified as signet-ring cell lymphoma based on morphology and CD20 expression.
Implications:
- This case highlights the importance of considering signet-ring cell lymphoma in the differential diagnosis of lytic bone lesions.
- Successful chemotherapy response suggests that conventional treatment protocols may be effective for this rare lymphoma variant.
- Further research into the pathogenesis and optimal treatment of signet-ring cell lymphoma is warranted.