[Bound form of ascorbic acid combined with the blood serum proteins]

The fractional distribution of combined forms of ascorbic acid in the blood serum of man and animals was studied by the method of gel-filtration with sephadex. The investigations revealed the presence of a free ascorbic acid and the one combined with high-molecular proteins and peptides. A difference in binding ascorbic acid with high molecular proteins and peptides was noted. Saturation of the organism with ascorbic acid leads to its increased binding within the peptides zone alone.