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In vitro antifungal activity of triterpenoid saponins
A Favel1, M D Steinmetz, P Regli
1Laboratoire de Botanique et Cryptogamie, Faculté de Pharmacie, Marseille, France.
Planta Medica
|February 1, 1994
Abstract:
The antifungal activity of triterpenoid saponins, with hederagenin or oleanolic acid as aglycone, was investigated in vitro by the agar dilution method. Monodesmosidic hederagenin derivatives were shown to exhibit a broad spectrum of activity against yeast as well as dermatophyte species. alpha-Hederin was the most active compound, and Candida glabrata was the most susceptible strain. The structure-activity relationships are discussed.