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Functioning adrenal cortical carcinoma in pregnancy

F A White

    Southern Medical Journal
    |March 1, 1994
    PubMed
    Summary

    Functioning adrenal cortical carcinoma during pregnancy is extremely rare. Despite aggressive treatment, maternal survival remains poor, though fetal outcomes are generally good.

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    Area of Science:

    • Endocrinology
    • Oncology
    • Obstetrics

    Background:

    • Adrenal cortical carcinoma (ACC) is a rare endocrine malignancy.
    • Concurrent pregnancy and ACC is exceptionally uncommon, with limited documented cases.

    Observation:

    • Presents two additional cases of functioning adrenal cortical carcinoma diagnosed during pregnancy.
    • Both cases involved advanced disease and aggressive tumor behavior.

    Findings:

    • Despite surgical intervention and chemotherapy, both patients succumbed to adrenal cortical carcinoma.
    • Maternal prognosis for functioning ACC in pregnancy is extremely poor.

    Implications:

    • Highlights the critical rarity and poor maternal prognosis of functioning adrenal cortical carcinoma during pregnancy.
    • Emphasizes the need for multidisciplinary management and further research into effective treatments.
    • Suggests that fetal prognosis may be favorable despite the maternal diagnosis.

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