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Crystalloids in metastatic prostatic adenocarcinoma
K H Molberg1, A Mikhail, F Vuitch
1Department of Pathology, University of Texas Southwestern Medical Center at Dallas 75235-9072.
American Journal of Clinical Pathology
|March 1, 1994
Summary
Eosinophilic crystalloids, typically seen in prostate cancer, can rarely appear in locally advanced cases. Their presence may indicate a prostatic origin for lung adenocarcinomas of unknown primary site.
Area of Science:
- Oncology
- Pathology
Background:
- Metastatic prostate cancer can present with diverse histological features.
- Distinguishing primary lung tumors from metastatic disease is clinically significant.
Observation:
- A case of metastatic prostate cancer mimicking a primary lung tumor was identified.
- The lung tumor exhibited characteristic eosinophilic crystalloids within malignant glands.
Findings:
- Eosinophilic crystalloids were not found in metastases from 30 prostate cancer patients.
- Crystalloids were observed in the bladder extension of one patient with locally advanced prostate adenocarcinoma.
Implications:
- The presence of eosinophilic crystalloids may serve as a diagnostic marker for prostatic origin.
- This finding aids in diagnosing adenocarcinomas of uncertain primary origin.