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Reproductive failure in a patient with neurofibromatosis-Noonan syndrome
D Meschede1, U G Froster, F Gullotta
1Institutes of Reproductive Medicine, Münster, Germany.
American Journal of Medical Genetics
|September 1, 1993
Abstract:
We report on a 39-year-old man with neurofibromatosis-Noonan syndrome and long-standing infertility. Comprehensive testing did not uncover any significant endocrine abnormalities, but the testicular seminiferous epithelium was found to be severely compromised. While the occasional association of neurofibromatosis with signs of Noonan syndrome has been reported, reproductive failure has not been previously described in this condition.