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Postnatal somatic and mental development after periconceptional multivitamin supplementation
1Department of Human Genetics and Teratology, National Institute of Hygiene-WHO Collaborating Centre for the Community Control of Hereditary Diseases, Budapest, Hungary.
Archives of Disease in Childhood
|March 1, 1994
Summary
Periconceptional multivitamin supplementation showed no significant impact on infant mortality or overall development. However, a higher incidence of atopic dermatitis was observed in infants whose mothers took multivitamins.
Area of Science:
- Obstetrics and Gynecology
- Pediatrics
- Nutritional Science
Background:
- Periconceptional nutrient intake is crucial for fetal development.
- Multivitamin supplementation is common practice for pregnant women.
- Understanding the long-term effects on infant development is essential.
Purpose of the Study:
- To evaluate the impact of periconceptional multivitamin supplementation on postnatal infant development.
- To compare the effects of a multivitamin tablet (Elevit Pronatal) versus a trace element tablet.
Main Methods:
- Randomised controlled trial involving 4122 liveborn infants.
- Postnatal follow-up of 3713 infants (90.1%) up to 8 months of age.
- Assessment of mortality, serious/chronic disorders, somatic, mental, and behavioral development.
Main Results:
- No significant differences in infant mortality rates between multivitamin and trace element groups.
- No significant differences in somatic development (weight, length, head circumference).
- Higher incidence of atopic dermatitis in the multivitamin group (15 vs. 4 cases).
Conclusions:
- Periconceptional multivitamin supplementation did not significantly affect infant mortality or overall development.
- A potential association between multivitamin use and increased risk of atopic dermatitis warrants further investigation.
- Trace element supplementation may be a viable alternative for certain outcomes.