Related Experiment Videos
Synthesis of antitumour carbon-bridged imidazopyridazine carbamates
C V Denyer1, M T Reddy, D C Jenkins
1Department of Medicinal Chemistry, Wellcome Research Laboratories, Beckenham, Kent, U.K.
Archiv Der Pharmazie
|February 1, 1994
Abstract:
Two carbon-bridged analogues 11 and 15 of the potent microtubule inhibitor BW1069C85 (1) have been synthesised and evaluated for antitubulin and antitumour activity in vitro. Though the compounds were somewhat less potent than BW1069C85, significant activity against tubulin polymerisation and cell proliferation was demonstrated in the assays.