Obsessions, responsibility and guilt: two case reports suggesting a common and specific aetiology
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Updated: Nov 9, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
1Department of Psychological Medicine, Chelsea & Westminster Hospital, London, U.K.
Abstract:
Inflated responsibility, guilt and the psychological fusion of thought and action feature prominently in contemporary accounts of obsessional phenomena. Two cases are reported in which the presence of these features can be explained by a specific formative learning experience. Some implications for therapy are considered.
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