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Effects of nitric oxide on red blood cells: changes in erythrocyte resistance to hypotonic hemolysis and potassium
C Caramelo1, A Riesco, J Outeiriño
1Instituto de Investigaciones Médicas, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
Biochemical and Biophysical Research Communications
|March 15, 1994
Abstract:
To determine the role of nitric oxide (NO)-dependent mechanisms on erythrocyte properties, we exposed red cells to L-arginine competitive analogues, 8Br-cyclic guanosine monophosphate (8Br-cGMP) and neutrophil-eliminating filters. These treatments significantly decreased hypotonic hemolysis, increased potassium efflux and caused a spiculate change in erythrocyte morphology. These effects were related to a decrease of NO caused by the three types of treatments.