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Oxygen consumption changes with stored blood infusions

J T Oman-McDanal, G T Smith, G T Suehiro

    Annals of Surgery
    |August 1, 1975
    PubMed
    Summary
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    Massive stored blood transfusions, especially unfiltered, significantly increase oxygen consumption. This heightened demand can contribute to irreversible shock in trauma patients.

    Area of Science:

    • Transfusion Medicine
    • Critical Care Medicine
    • Pulmonary Physiology

    Background:

    • Microaggregates in stored blood are linked to post-traumatic pulmonary insufficiency.
    • The precise impact of stored blood components on physiological parameters requires further investigation.

    Purpose of the Study:

    • To investigate the effects of autologous and homologous blood infusions (stored, filtered, unfiltered, and fresh) on pulmonary function and hemodynamics.
    • To identify specific transfusion components or conditions that influence oxygen consumption and demand.

    Main Methods:

    • Infusion of autologous stored (filtered and unfiltered) and homologous stored and fresh blood in a study setting.
    • Monitoring of pulmonary function and hemodynamic parameters.
    • Measurement of oxygen consumption.

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    Main Results:

    • Inconsistent changes were observed in pulmonary hemodynamics and blood oxygenation across different transfusion types.
    • A significant increase in oxygen consumption was noted exclusively with unfiltered autologous or homologous stored blood infusions.
    • Fresh or filtered blood did not elicit the same increase in oxygen consumption.

    Conclusions:

    • Unfiltered stored blood transfusions markedly elevate oxygen consumption, posing a challenge to oxygen delivery in critically injured patients.
    • This increased oxygen demand may be a critical factor in the development of irreversible shock following massive blood transfusions.
    • Filtering stored blood or using fresh blood may mitigate this adverse effect on oxygen metabolism.