N4-(arylmethylene)-N1-[1-(1,2,5,6-tetrahydropyridyl)]-sulphanilamide derivatives as novel possible hypoglycemic...

Two series of sulphanilamide derivatives (Va-i and Vla-i), comprising both azomethine and arylsulphonamidotetrahydropyridine moieties, were especially synthesized to investigate the additive effect of such moieties on the pharmacological activity of the produced sulphonamides as possible therapeutic agents for producing hypoglycemia. Most of the hitherto prepared sulphanilamide derivatives, exhibited marked hypoglycemic activity. Structure-activity relationships were investigated and discussed, not only on the basis of lipophilic (pi) and/or electronic (sigma) characters of the aromatic substituent (R), but also in light of a steric effect in these molecules. The structure of the newly synthesized compounds was inferred from elemental and spectral analysis.