Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T cells and their role in allergies

D Wilhelm1, H Kirchner

  • 1Institute of Immunology and Transfusion Medicine, University of Lübeck, FRG.

Experimental and Clinical Immunogenetics
|January 1, 1993
PubMed
Summary

Understanding the regulation of immunoglobulin E (IgE) synthesis in atopic patients is incomplete. T helper 2 (TH2) cells and their derived cytokines, like interleukin-4 (IL-4), are key drivers of IgE production.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deconvolution of 1D NMR spectra: A deep learning-based approach.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2022
Same author

Usage of a graph database for the selection of sterile items in the OR.

International journal of computer assisted radiology and surgery·2022
Same author

[The importance of microbiological results for the treatment of complicated appendicitis-a monocentric case-control study].

Chirurgie (Heidelberg, Germany)·2022
Same author

[Image-based supportive measures for future application in surgery].

Chirurgie (Heidelberg, Germany)·2022
Same author

Surgical reporting for laparoscopic cholecystectomy based on phase annotation by a convolutional neural network (CNN) and the phenomenon of phase flickering: a proof of concept.

International journal of computer assisted radiology and surgery·2022
Same author

[Clinical value of alternative technologies to standard laparoscopic cholecystectomy - single port, reduced port, robotics, NOTES].

Chirurgie (Heidelberg, Germany)·2022

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Biology

Background:

  • The precise molecular and cellular mechanisms driving elevated immunoglobulin E (IgE) synthesis in atopic individuals remain incompletely elucidated.
  • T cells are recognized as critical players in orchestrating the B cell immunoglobulin switch to IgE.

Purpose of the Study:

  • To explore the role of T cells, particularly T helper 2 (TH2) cells, and their secreted cytokines in regulating IgE synthesis.
  • To investigate the mechanisms of B cell activation and IgE class switching in the context of atopic disease.

Main Methods:

  • Analysis of T cell subsets (TH1 vs. TH2) and their cytokine profiles in atopic patients.
  • Investigation of the effects of various cytokines (e.g., IL-4, IL-5, IFN-gamma) on B cell activation and IgE production.
  • Assessment of B cell activation signals, including T cell-B cell interaction and anti-CD40 stimulation.

Main Results:

  • Interleukin-4 (IL-4) is a specific inducer of IgE synthesis, promoting B cell proliferation and cytokine release that enhances IgE production.
  • Costimulatory signals, such as anti-CD40, are necessary for B cell activation and the IgE switch.
  • TH2-derived cytokines amplify IgE synthesis, while TH1-derived cytokines like interferon-gamma (IFN-gamma) inhibit it.
  • Atopic patients exhibit allergen-specific T cells with a TH2-like lymphokine profile and a predominance of TH2 cells, correlating with increased serum IgE.

Conclusions:

  • The predominance of TH2 cells and their associated lymphokines in atopic patients likely contributes to elevated serum IgE concentrations.
  • The specific stimuli leading to TH2 cell predominance over TH1 cells in atopy require further investigation.

Related Experiment Videos