Related Experiment Video
Updated: Aug 16, 2026
Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Clonal chromosomal abnormalities in Fanconi's anaemia: what do they really mean?
B P Alter1, A Scalise, J McCombs
1Polly Annenberg Levee Hematology Center, Mount Sinai School of Medicine, New York, N.Y.
Abstract:
Patients with Fanconi's anaemia (FA) have aplastic anaemia, leukaemia, myelodysplasia and tumours. Since leukaemia has a very poor prognosis, it is desirable to identify high-risk patients. To determine the significance of clonal marrow chromosomal abnormalities we began a prospective study in 17 patients: five were normal, eight aplastic, and four myelodysplastic. Three of 11 with adequate cytogenetics had transient abnormal clones. None had leukaemia at 3-24 months. Changing cytogenetic patterns may not be related to leukaemic evolution in patients with a DNA repair defect.
Related Concept Videos
01:17Karyotyping
01:39Mutations
01:27Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...