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[Thyroid nodule disease in a previously endemic goiter area]
R Gómez de la Torre1, A Enguix Armada, L García
1Servicio de Medicina Interna, Hospital Carmen y Severo Ochoa, Cangas del Narcea, Asturias.
Anales De Medicina Interna (Madrid, Spain : 1984)
|October 1, 1993
Summary
Thyroid nodular disease incidence was 0.4 per 1,000 yearly in a goitrogenic area. Iodine supplementation did not alter disease behavior but caused iodine-induced hyperthyroidism in 8.2% of patients.
Area of Science:
- Endocrinology
- Thyroidology
- Public Health
Context:
- A 6-year study involving 110 patients with thyroid nodular disease was conducted in a region historically known for goiter.
- The study area had recently undergone an iodation campaign to address iodine deficiency.
Purpose:
- To determine the incidence of thyroid nodular disease in the studied population.
- To compare the clinical and analytical characteristics of multinodular goiter and autonomous thyroid nodules.
- To assess the impact of iodine supplementation on the development of iodine-induced thyrotoxicosis.
Summary:
- The incidence of thyroid nodular disease was found to be 0.4 per 1,000 population per year.
- Multinodular goiter and autonomous thyroid nodules exhibited similar clinical and analytical profiles.
- Hyperthyroidism was prevalent (58.2%), including T-4 thyrotoxicosis, T-3 thyrotoxicosis, and subclinical hyperthyroidism.
- Iodine-induced hyperthyroidism (Jod Basedow) occurred in 8.2% of patients, identified by elevated iodide excretion levels.
Impact:
- This research provides crucial data on thyroid nodular disease epidemiology in formerly goitrogenic areas post-iodation.
- Findings highlight the need for monitoring thyroid function after iodine supplementation to prevent iatrogenic hyperthyroidism.
- The study underscores that multinodular goiter and autonomous nodules share similar clinical presentations, simplifying diagnostic approaches.