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Updated: Aug 11, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
[Hepatitis C in primary care: a study of carriers and their families]
A M Gómez1, J J González Marco, E Moreno González
1Centro de Salud de la Chopera, Alcobendas, Madrid.
Insights
Hepatitis C virus (HCV) antibody prevalence was higher in family contacts than the general population, with many cases of unknown origin. Primary care plays a key role in detecting and managing HCV infection.
Area of Science:
- Epidemiology
- Infectious Diseases
- Hepatology
Objective:
A clinical epidemiological study at a health centre of carriers of hepatitis C virus (HCV) antibodies. The prevalence of HCV antibodies in immediate family members.
Design:
Crossover and descriptive.
Setting:
Chopera I Primary Care team. PATIENTS AND FAMILY MEMBERS: 37 carriers of HCV antibodies in the Centre's records. 52 family members of 21 carriers.
Measurements And Main Results:
A form containing the clinical and epidemiological data of each carrier was filled out. The diagnosis of HCV infection was made at the Health Centre in 72.22% of cases. 80% evolved towards a chronic hepatitis. 56.75% had a history of parenteral transmission. 37.75% had no history of risk factors. The epidemiological data of the family members was recorded and transaminasaemia and the HCV antibodies were determined. Four cases (8.33%) with altered transaminase and three cases (6.82%) of positive antibodies were found.
Conclusions:
Existence of a high percentage of Hepatitis C of no known origin and a greater prevalence of carriers among family contacts than in the population as a whole. Essential role of Primary Care in the detection and follow-up of HCV carriers. A need for definitive studies on sexual transmission and the possible existence of other transmission routes. The setting-up of preventive measures against these routes.
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