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[Sequential observation on the influence of artificial wind-cold environment to immunologic function of mononuclear
Abstract:
According to TCM theory of Six Evils, the Wind-Cold is one of the pathogen. In order to find the mechanism of Wind-Cold in causing disease, the effect of subacute Wind-Cold stimulation on the phagocyte immunization in mice was observed. Results showed that through exposing in the Wind-Cold environment, the reticuloendothelial system (RES) clearance function and the hydrogen-peroxide releasing of peritoneal macrophage were suppressed. Sequential observation showed that the peak of immunosuppression occurred on the 3rd day after stimulation and began to normalize at 5th day. These results suggested that Wind-Cold stimulation could inhibit temporary phagocytosis of macrophage and bacteriocidal effect. Action of immunosuppression was believed to be produced by the increase of stress hormone after stimulation. Results also suggested that the pathogenic action of Wind-Cold on disease is somewhat related with the suppression of nonspecific cellular immunity.
Insights
Wind-Cold exposure suppresses immune cell function in mice, impacting phagocytosis and bacterial defense. This immunosuppression, linked to stress hormones, highlights a potential mechanism for Wind-Cold in disease pathogenesis.
Area of Science:
- Immunology
- Traditional Chinese Medicine (TCM)
Context:
- The theory of Six Evils in TCM identifies Wind-Cold as a pathogenic factor.
- Understanding the mechanisms by which environmental factors influence immunity is crucial.
Purpose:
- To investigate the impact of subacute Wind-Cold stimulation on the immune system in a mouse model.
- To elucidate the role of Wind-Cold in disease pathogenesis by examining its effects on phagocytic cells.
Summary:
- Exposure to a Wind-Cold environment suppressed the reticuloendothelial system (RES) clearance function in mice.
- Peritoneal macrophage hydrogen-peroxide release, a key indicator of immune activity, was significantly inhibited.
- Immunosuppression peaked on day 3 and began normalizing by day 5, suggesting a temporary but potent effect.
- Stress hormone increase is hypothesized as the mediator of this Wind-Cold-induced immunosuppression.
Impact:
- Wind-Cold stimulation temporarily inhibits macrophage phagocytosis and bactericidal effects.
- These findings suggest that Wind-Cold's pathogenic action is associated with the suppression of non-specific cellular immunity.
- This research provides insights into the immunological basis of Wind-Cold-related illnesses in TCM.