CNS effects on gastric functions: from clinical observations to peptidergic brain-gut interactions

Clinical observations as early as the last century pointed to the stomach's link to the brain. Animal studies in this century have given us detailed information about the neuroanatomical and neurophysiological basis of brain-gut interactions. Psychological stress models and stereotaxic brain procedures have been important tools in gaining this information. During the last 10 years, there has been much focus on the effects of neuropeptides on gastric functions. Several CNS-peptides have indeed been shown to influence multiple gastric functions such as: acid secretion, bicarbonate secretion, mucus secretion, motility, blood flow and prostaglandin synthesis. Accordingly, direct CNS-application of these peptides also influences the development of gastric erosions during experimental stress procedures.