Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydroxychloroquine, dosage parameters and retinopathy

D J Spalton1, G M Verdon Roe, G R Hughes

  • 1Department of Medical Ophthalmology, St. Thomas' Hospital, London, UK.

Lupus
|December 1, 1993
PubMed
Summary

Hydroxychloroquine retinopathy is unlikely at doses under 6.5 mg/kg with less than 10 years of treatment. Current screening guidelines for antimalarial therapy may be too rigorous, with visual field testing offering limited benefit.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Re: The report 'irrigation of the capsular bag using a sealed-capsule irrigation device and 5-fluorouracil' by Milverton.

Eye (London, England)·2010
Same author

Diagnostic accuracy and variability of autorefraction by the Tracey Visual Function Analyzer and the Shin-Nippon NVision-K 5001 in relation to subjective refraction.

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)·2009
Same author

Interplay of aberrations and visual parameters in pseudophakic eyes.

Eye (London, England)·2008
Same author

Intravitreal triamcinalone acetonide for refractory uveitic cystoid macular oedema: longterm management and outcome.

Acta ophthalmologica Scandinavica·2005
Same author

Steroid prophylaxis in eyes with uveitis undergoing phacoemulsification.

The British journal of ophthalmology·2004
Same author

A mathematical model of factors that influence the performance of accommodative intraocular lenses.

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)·2004

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Pharmacology

Background:

  • Hydroxychloroquine is commonly prescribed for autoimmune conditions.
  • Long-term use may be associated with ocular toxicity, specifically retinopathy.
  • Ophthalmic screening guidelines aim to detect this toxicity early.

Purpose of the Study:

  • To investigate the prevalence of retinopathy in patients using hydroxychloroquine.
  • To assess the correlation between drug dosage/duration and visual field function.
  • To evaluate the necessity of current ophthalmic screening protocols.

Main Methods:

  • Compared 82 patients on hydroxychloroquine (over 1 year) with controls.
  • Utilized fundoscopy, fundus photography, and automated macular visual fields.
  • Analyzed drug usage, dosage (mg/kg), and treatment duration.

Main Results:

  • No retinopathy was detected in any patient taking hydroxychloroquine.
  • No correlation found between visual field indices and drug exposure parameters.
  • Retinopathy appears unlikely below 6.5 mg/kg with <10 years of treatment.

Conclusions:

  • Current ophthalmic screening guidelines for hydroxychloroquine users may be overly stringent.
  • Automated visual field testing may not be beneficial for detecting hydroxychloroquine retinopathy.
  • Recommendations for revised ophthalmic supervision are proposed.

Related Experiment Videos