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Pharmacokinetics of alkylating agents
1Department of Clinical Oncology, Newcastle General Hospital, Newcastle upon Tyne.
Cancer Surveys
|January 1, 1993
Abstract:
Alkylating agents have been used for over 30 years in the treatment of malignant disease. Because of their very reactive nature, studies of their intermediate metabolism have been difficult. However, this is now possible with modern analytical techniques. Further understanding of their metabolism and pharmacokinetics should lead to a more rational use in the clinic.