Search research articles

Search research articles

Related Experiment Videos

Thyroid hormones in differentiated thyroid cancer

A M Samuel¹, M N Mehta, K B Desai

¹Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Parel, Bombay.

Clinical Nuclear Medicine

|January 1, 1994

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Missing data may lead to changes in hip fracture database studies: a study of the American College of Surgeons National Surgical Quality Improvement Program.

The bone & joint journal·2018

Same author

Surgery for a fracture of the hip within 24 hours of admission is independently associated with reduced short-term post-operative complications.

The bone & joint journal·2017

Same author

Do we really know our patient population in database research? A comparison of the femoral shaft fracture patient populations in three commonly used national databases.

The bone & joint journal·2016

Same author

General versus spinal anaesthesia for patients aged 70 years and older with a fracture of the hip.

The bone & joint journal·2015

Same author

Mycobacterium tuberculosis 38kDa antigen and its encoding gene-experience in diagnostic applications.

Indian journal of clinical biochemistry : IJCB·2012

Same author

Guidelines in the management of thyroid cancer.

The Journal of the Association of Physicians of India·2011

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Radioiodine therapy effectiveness in differentiated thyroid cancer varies. Patients with functioning metastases and normal hormone levels showed poor response, while those with low thyroglobulin and hormone synthesis responded better.

Area of Science:

Endocrinology
Nuclear Medicine
Oncology

Background:

Differentiated thyroid cancer (DTC) management often involves radioiodine therapy.
Predicting treatment response in metastatic DTC remains a clinical challenge.
Thyroglobulin (Tg) levels and hormone synthesis by metastases are potential biomarkers.

Purpose of the Study:

To evaluate the impact of metastatic disease characteristics on radioiodine therapy outcomes in differentiated thyroid cancer.
To investigate the relationship between thyroglobulin levels, hormone synthesis, and treatment response.

Main Methods:

Retrospective analysis of 136 differentiated thyroid cancer patients undergoing radioiodine therapy since 1991.
Assessment of metastatic disease, thyroglobulin levels, and evidence of thyroid hormone synthesis.

Related Experiment Videos

Correlation of these factors with patient response to radioiodine treatment.

Main Results:

80 of 136 patients had metastatic disease; 51 had elevated thyroglobulin (Tg).
15 patients had functioning metastases; 14 were follicular carcinomas with skeletal metastases and poor radioiodine response.
Patients with high Tg but low hormone synthesis, and those with low Tg and low hormone synthesis, showed better radioiodine response.

Conclusions:

Functioning metastases with normal circulating hormone levels predict poor radioiodine therapy response in DTC.
Elevated Tg with low hormone synthesis, and low Tg with low hormone synthesis, indicate better radioiodine uptake and treatment efficacy.
Radioiodine therapy outcomes in metastatic DTC are influenced by tumor characteristics and functional status.