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Dentifrices: recent clinical findings and implications for use

K W Stephen1

  • 1University of Glasgow Dental Hospital and School, UK.

International Dental Journal
|December 1, 1993
PubMed
Summary

Fluoride toothpaste efficacy is established between 1000-2800 ppm F. Sodium fluoride (NaF) in silica provides superior caries protection compared to SMFP, with brushing habits impacting results.

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Area of Science:

  • Dental research
  • Public health
  • Fluoride chemistry

Background:

  • Toothpaste formulations have evolved over 30 years to enhance active ingredient stability, compatibility, and bioavailability.
  • A dose-response relationship for fluoride efficacy is established between 1000-2800 ppm F, but effectiveness below 1000 ppm requires further study.

Purpose of the Study:

  • To evaluate the efficacy of different fluoride dentifrice formulations and concentrations.
  • To assess the impact of anti-calculus/anti-microbial agents on caries prevention.
  • To investigate the influence of brushing habits and age-related factors on fluoride dentifrice effectiveness.

Main Methods:

  • Meta-analysis of data from over 14,000 subjects across 12 studies.
  • Comparative analysis of sodium fluoride (NaF) versus sodium monofluorophosphate (SMFP) in various abrasive systems.
  • Longitudinal assessment of caries levels over 3 years, considering brushing frequency and rinsing behaviors.

Main Results:

  • Sodium fluoride (NaF) in a silica base demonstrates superior caries protection compared to NaF + SMFP or SMFP alone.
  • Anti-calculus and anti-microbial agents show no significant impact on caries levels.
  • Toothbrushing frequency and post-brushing rinsing habits significantly influence caries reduction over time.

Conclusions:

  • Optimized fluoride dentifrice formulations, particularly NaF in silica, enhance caries prevention.
  • Brushing practices are critical determinants of fluoride toothpaste effectiveness.
  • Careful consideration of dentifrice ingestion is necessary for children under 6-7 years, though fluorosis is not a significant public health concern in the UK based on current data.

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