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Prognosis of myocardial infarction and brain functional asymmetry
E I Nikolaeva1, E A Oteva, A A Nikolaeva
1Institute of Bioorganic Chemistry, Siberian Branch of Russian Academy of Science, Novosibirsk.
Insights
Brain hemisphere dominance impacts heart disease risk. Left hemisphere dominance in men is linked to more severe myocardial infarction and higher cholesterol. Right hemisphere dominance is associated with elevated cortisol and insulin levels.
Area of Science:
- Cardiology
- Neuroscience
- Biochemistry
Background:
- Myocardial infarction (MI) is a leading cause of death.
- Cerebral dominance refers to the lateralization of brain functions.
- The relationship between brain asymmetry and cardiovascular disease risk is not fully understood.
Purpose of the Study:
- To investigate the association between cerebral dominance and cardiovascular risk factors in patients with myocardial infarction.
- To compare blood biochemical markers in patients with left vs. right hemisphere dominance.
Main Methods:
- Seventy-eight male patients post-myocardial infarction were analyzed.
- Blood levels of cholesterol, lipoproteins, triglycerides, insulin, and cortisol were measured.
- Patients were categorized based on left or right hemisphere cerebral dominance.
Main Results:
- Patients with left hemisphere dominance exhibited more severe coronary atherosclerosis and significantly higher blood cholesterol and lipoprotein levels.
- Patients with right hemisphere dominance showed the highest concentrations of blood cortisol and insulin.
- Age of patients was a mean of 47.0 years.
Conclusions:
- Brain functional asymmetry may represent a novel risk factor for coronary atherosclerosis, particularly in individuals under 50.
- Cerebral dominance patterns are associated with distinct cardiovascular risk profiles.
Abstract:
Seventy-eight men (mean age, 47.0 +/- 1.1 years) who had suffered from myocardial infarction were examined. Blood cholesterol, lipoproteins, triglycerides, insulin and cortisol concentrations were compared in patients with left hemisphere or right hemisphere cerebral dominance. Patients with left hemisphere dominance had more serious disease and much higher levels of blood cholesterol and lipoproteins. Patients with right hemisphere dominance had the highest levels of blood cortisol and insulin. The brain's functional asymmetry may be one of the risk factors for coronary atherosclerosis in subjects under the age of 50 years.