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Withdrawal phenomenon after abrupt cessation of nifedipine in stable angina pectoris
S Y Martsevich1, N Koutishenko, V I Metelitsa
1Department of Preventive Pharmacology, Research Centre for Preventive Medicine of Russia, Moscow.
International Journal of Cardiology
|December 31, 1993
Abstract:
We investigated the effect of abrupt cessation of nifedipine after regular administration (20 mg, four times daily) for 5 weeks in seven patients with stable angina pectoris. A rebound decrease in exercise tolerance and increase of exercise-induced myocardial ischaemia were registered on the first day of nifedipine withdrawal.