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[The study on cerebral hemodynamics during selective cerebral perfusion]
1Second Department of Surgery, Niigata University School of Medicine, Japan.
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai
|February 1, 1994
Summary
Cerebral autoregulation remains intact during deep hypothermic selective perfusion (SCP). However, venous drainage obstruction increases intracranial pressure, reducing cerebral blood flow, while hyperperfusion may cause extracranial shunt flow.
Area of Science:
- Cardiovascular Physiology
- Neuroscience
- Surgical Research
Context:
- Deep hypothermic selective perfusion (SCP) is used in cardiac surgery.
- Understanding cerebral hemodynamics during SCP is crucial for patient outcomes.
- Venous drainage obstruction is a potential complication during SCP procedures.
Purpose:
- To characterize cerebral hemodynamics during deep hypothermic selective perfusion (SCP).
- To investigate the impact of superior vena cava (SVC) cannula obstruction on cerebral hemodynamics.
- To assess the correlation between perfusion pressure and cerebral blood flow (CBF) during SCP.
Summary:
- Carotid arterial pressure did not significantly correlate with carotid arterial flow (CAF), CBF, or intracranial pressure (ICP).
- Increased pump flow rate correlated with increased CAF, but not significantly with CBF.
- SVC cannula obstruction led to increased ICP and internal jugular vein pressure (IJVP), and decreased CAF (p < 0.05).
- Unclamping the SVC cannula reversed these effects, decreasing ICP and IJVP while increasing CAF and CBF.
Impact:
- Cerebral autoregulation appears intact during deep hypothermic SCP.
- Increased ICP due to venous drainage obstruction can impede cerebral blood flow.
- Hyperperfusion may lead to increased extracranial shunt flow, affecting cerebral perfusion.
- Findings provide insights into managing cerebral hemodynamics during SCP and preventing complications.