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Related Experiment Videos

Microencapsulation within crosslinked polyethyleneimine membranes

D Poncelet1, T Alexakis, B Poncelet de Smet

  • 1Department of Chemical Engineering, McGill University, Montreal, Quebec, Canada.

Journal of Microencapsulation
|January 1, 1994
PubMed
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A novel microencapsulation method uses polyethyleneimine (PEI) membranes crosslinked with acid dichloride. This technique offers a robust and efficient way to encapsulate sensitive biomaterials, outperforming traditional polyamide methods.

Area of Science:

  • Biomaterials Science
  • Chemical Engineering
  • Polymer Chemistry

Background:

  • Microencapsulation is crucial for protecting sensitive biomaterials.
  • Existing methods, like those using polyamide membranes, have limitations for certain applications.
  • Developing new microencapsulation techniques is essential for advancing biocatalysis and biochemical storage.

Purpose of the Study:

  • To introduce a new microencapsulation technique using polyethyleneimine (PEI) membranes.
  • To evaluate the suitability of this PEI-based method for encapsulating biocatalysts and fragile biochemicals.
  • To characterize the properties of the resulting PEI microcapsules.

Main Methods:

  • A microencapsulation process was developed utilizing polyethyleneimine (PEI) membranes.

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  • Membranes were formed via crosslinking with an acid dichloride in a non-polar solvent at pH 8.
  • Characterization included assessment of microcapsule diameter, size distribution, morphology, and membrane mass.

    • Main Results:

    • PEI microcapsules exhibited spherical shape, free-flowing properties, and strong membranes.
    • The mean diameter and size distribution were comparable to those obtained with nylon membranes.
    • Membrane mass was independent of reaction time and PEI concentration but proportional to the crosslinking agent concentration.

    Conclusions:

    • The proposed PEI microencapsulation technique is suitable for fragile biomaterials.
    • This method provides an effective alternative to polyamide-based microencapsulation.
    • The process offers control over microcapsule properties through crosslinking agent concentration.