[Comparative subcellular localization of para-hydroxylated derivatives of ephedrine and amphetamine in rat brain]

Localisation of noradrenaline, hydroxyamphetamine, hydroxynorephedrine and hydroxyephedrine was studied in adrenergic granules of rat's brain in normal animals and in animals injected with hydroxy-6 dopamine. In normal animals the synaptosomes fixed noradrenaline, first and then, in decreasing order, hydroxynorephedrine, hydroxyephedrine and hydroxyamphetamine. Hydroxy-6 dopamine injection resulted in a decrease of fixation by synaptosomes, thus confirming the role of central false-transmitters of hydroxylated derivatives of amphetamine and ephedrine.