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Immunophenotyping of acute lymphoblastic leukaemia in Madras, India
K R Rajalekshmy1, A R Abitha, R Pramila
1Haematology/Immunology Division, Cancer Institute, Adyar, Madras, South India.
Leukemia Research
|March 1, 1994
Abstract:
At the Cancer Institute, Madras, India, we have performed immunophenotyping in 125 untreated cases of acute lymphoblastic leukaemia using a panel of 16 monoclonal antibodies and the avidin-biotin immunoperoxidase technique in a haematology autoanalyser (Technicon Hi system). Our results demonstrate a marked difference in the phenotypic pattern of ALL compared to Western countries, the predominant finding being a relative excess of T-ALL and a paucity of C-ALL cases. Age distribution of C-ALL reveals a peak at 2-6 years in paediatric ALL cases.