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A functional MRI technique combining principles of echo-shifting with a train of observations (PRESTO)
1In Vivo NMR Research Center, BEIP, NCRR, National Institutes of Health, Bethesda, MD 20892.
Abstract:
We present a fast MRI technique sensitized to microscopic susceptibility effects. The method combines elements of echo-shifted gradient-recalled MR imaging (TE > TR) with the acquisition of multiple k-space lines within a single TR-period. The sequence results in a much reduced imaging time as compared with conventional gradient-echo MRI methods. The feasibility of the method is demonstrated for susceptibility bolus tracking in the cat brain using an imaging time of 153 ms. The relative cerebral blood volume maps created with this method are comparable with those obtained with conventional methods.
Insights
This study introduces a rapid magnetic resonance imaging (MRI) method for detecting microscopic susceptibility effects. The new technique significantly reduces scan times, enabling fast susceptibility bolus tracking in the brain.
Area of Science:
- Medical Imaging
- Neuroimaging
- Biophysics
Background:
- Microscopic susceptibility effects are crucial for understanding brain physiology and pathology.
- Conventional gradient-echo MRI methods can be time-consuming for dynamic susceptibility studies.
- There is a need for faster MRI techniques to capture rapid physiological processes.
Purpose of the Study:
- To develop and validate a fast MRI technique sensitive to microscopic susceptibility effects.
- To reduce imaging time compared to conventional gradient-echo MRI.
- To demonstrate the feasibility of the technique for susceptibility bolus tracking in vivo.
Main Methods:
- The technique combines echo-shifted gradient-recalled MR imaging (TE > TR) with multi-line k-space acquisition per TR.
- This approach allows for accelerated data acquisition within a single TR period.
- The method was tested for susceptibility bolus tracking in a cat brain model.
Main Results:
- The developed MRI sequence achieved a significantly reduced imaging time of 153 ms.
- Susceptibility bolus tracking in the cat brain was successfully demonstrated.
- Relative cerebral blood volume maps generated were comparable to those from conventional MRI methods.
Conclusions:
- The novel fast MRI technique is effective for detecting microscopic susceptibility effects.
- This method offers a substantial reduction in imaging time for dynamic susceptibility imaging.
- The technique shows promise for advanced neuroimaging applications, including real-time physiological monitoring.