Related Experiment Video

Updated: Aug 15, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

[Skin lesions as a rare initial symptom of Kahler's disease]

K M van Tol1, G Fedder

  • 1Locatie Lukas Ziekenhuis, afd. Inwendige Geneeskunde, Ziekenhuis Centrum Apeldoorn.

Nederlands Tijdschrift Voor Geneeskunde
|March 5, 1994
PubMed

Insights

This case study highlights a rare presentation of IgD multiple myeloma (Kahler's disease), where skin plasmacytomas were the initial symptom. Despite treatment, the disease progressed rapidly, leading to the patient's death within a year.

Area of Science:

  • Hematology
  • Oncology
  • Dermatology

Background:

  • Multiple myeloma is a plasma cell malignancy.
  • IgD multiple myeloma is a rare subtype with aggressive progression.
  • Extraskeletal involvement is common in IgD multiple myeloma.

Observation:

  • A 70-year-old male presented with multiple skin lesions.
  • Pathological examination confirmed plasmacytomas.
  • Bone marrow biopsy revealed 15% abnormal plasma cells and IgD paraprotein.

Findings:

  • The patient was diagnosed with IgD multiple myeloma (Kahler's disease).
  • Skin plasmacytomas as the initial symptom are exceptionally rare.
  • The disease followed a rapidly progressive course despite initial treatment response.

Implications:

  • This case underscores the importance of considering rare presentations of multiple myeloma.
  • Early recognition of cutaneous plasmacytomas may aid in diagnosing aggressive myeloma subtypes.
  • Understanding rare manifestations is crucial for comprehensive cancer management.

More Related Videos

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...