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Vigabatrin as an anticonvulsant against pentylenetetrazol seizures
1DETAM (Institute for Biological and Medical Research), Istanbul Faculty of Medicine, Capa, Turkey.
Pharmacological Research
|December 1, 1993
Abstract:
The anticonvulsant effects of gamma vinyl GABA (GVG) were investigated against pentylenetetrazol (PTZ) seizures, while sodium valproate (VP) was used as positive control. At 1000 and 1500 mg kg-1 GVG was found to decrease seizure intensity either in 4 or 24 h, as effectively as VP. At 2000 mg kg-1 GVG was found to be almost ineffective. At both doses and both time spans of drug action, seizure latency was prolonged, compared to controls and VP group.