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Updated: Jul 29, 2026
09:39
Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
Published on: May 30, 2013
Cannabis, hypochlorhydria, and cholera
Lancet (London, England)
|October 21, 1978
Summary
Frequent beer consumption increases stomach acid, while heavy cannabis use lowers it. Cannabis use may also worsen diarrhea caused by bacterial infections like cholera.
Area of Science:
- Gastroenterology
- Microbiology
- Vaccinology
Background:
- Understanding the impact of lifestyle factors on gastrointestinal health is crucial.
- Investigating potential predisposing factors for infectious diarrhea is important for public health.
Purpose of the Study:
- To examine the relationship between alcohol and cannabis consumption and stomach acid levels.
- To assess the association between cannabis use and the severity of bacterial diarrhea.
Main Methods:
- Observational study involving 90 volunteers for stomach acid analysis.
- Infectious diarrhea challenge study with 92 volunteers using Vibrio cholerae and enterotoxigenic Escherichia coli.
Main Results:
- High beer consumption (>3 days/week) correlated with increased stomach acid output.
- Heavy cannabis smoking (>2 days/week) was linked to reduced stomach acid output.
- Heavy cannabis users experienced more voluminous diarrhea when challenged with bacteria.
Conclusions:
- Alcohol and cannabis consumption significantly influence gastric acid secretion.
- Cannabis use may be a significant risk factor for developing severe bacterial diarrhea.
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