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Vaginal lactobacillosis

B J Horowitz1, P A Mårdh, E Nagy

  • 1University of Connecticut School of Medicine, Hartford, CT.

American Journal of Obstetrics and Gynecology
|March 1, 1994
PubMed
Summary
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Lactobacilli vaginosis, characterized by cyclic vaginal discharge and discomfort, is linked to unusually long lactobacilli. This condition can be effectively treated with antibiotics, though the cause of the morphologic change remains unknown.

Area of Science:

  • Microbiology
  • Gynecology

Background:

  • Vaginal discharge and discomfort can occur cyclically before menses.
  • This condition is associated with the presence of elongated, rod-like organisms in wet mount preparations.

Purpose of the Study:

  • To investigate a cyclic vaginal condition linked to specific microbial morphology.
  • To analyze the vaginal flora and identify associated organisms.

Main Methods:

  • Prospective study of 37 patients and 30 controls.
  • Analysis of vaginal flora, including anaerobic bacteria and fungi.
  • Identification and antibiotic susceptibility testing of isolated lactobacilli species.

Main Results:

  • 97% of patients with vaginosis had anaerobic lactobacilli; 40% of controls did.

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  • Organisms in patients averaged 60 microns, compared to 10 microns in controls.
  • Amoxicillin/clavulanate potassium effectively treated symptoms and eliminated elongated organisms.

    • Conclusions:

    • Lactobacilli vaginosis is characterized by extremely long lactobacilli.
    • The etiology of this morphologic transformation is currently unknown.
    • Antibiotic therapy offers an effective treatment for this condition.