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Related Experiment Videos

Axial flow ventricular assist device: system performance considerations

G Damm1, K Mizuguchi, G Aber

  • 1Department of Surgery, Baylor College of Medicine, Houston, TX 77030.

Artificial Organs
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

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Researchers are developing an implantable left ventricular assist device (LVAD) for long-term circulatory support. Improvements in pump design have achieved efficient power usage and reduced blood damage, with ongoing studies to further enhance performance and biocompatibility.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Medical Device Development

Background:

  • Developing long-term implantable circulatory support devices is crucial for managing heart failure.
  • Existing left ventricular assist devices (LVADs) face challenges in duration, efficiency, and biocompatibility.
  • A cooperative effort is focused on creating an advanced LVAD for extended use.

Purpose of the Study:

  • To systematically improve an implantable axial pump for long-term (over 3 months) circulatory support.
  • To enhance the efficiency and hemocompatibility of the LVAD.
  • To evaluate the antithrombogenic properties of the device through in vivo studies.

Main Methods:

  • Methodical evaluation and iterative testing of an implantable axial pump design.

Related Experiment Videos

  • Incorporation of an inducer element and an efficient brushless direct current motor.
  • In vivo feasibility studies in calves to assess antithrombogenic performance.

    • Main Results:

    • Achieved efficient power consumption: less than 10 W for 5 L/min flow against 100 mm Hg.
    • Attained a low index of hemolysis (0.021 g/100 L), indicating reduced blood damage.
    • Two-day in vivo studies in calves are currently underway.

    Conclusions:

    • The developed implantable axial pump shows promise for long-term circulatory support.
    • Ongoing empirical studies, computational modeling, and in vivo testing aim to further optimize device efficiency and hemocompatibility.
    • The LVAD is expected to provide significant advancements in managing pulmonary or systemic circulatory support needs.