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Disseminated pancreatic polypeptidioma

H Sakai1, S Kodaira, K Ono

  • 1Department of Medicine, Hokushin General Hospital, Nagano.

Internal Medicine (Tokyo, Japan)
|September 1, 1993
PubMed
Summary
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Pancreatic polypeptidioma is a rare pancreatic endocrine tumor. This case highlights a prompt response of bone metastases to radiotherapy in a disseminated disease.

Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Pancreatic polypeptidioma is an extremely rare pancreatic endocrine tumor.
  • Limited data exists on its clinical features and therapeutic responses.

Observation:

  • A 33-year-old woman presented with disseminated pancreatic polypeptidioma.
  • She exhibited metastases including bone pain, cranial nerve palsy, spinal block, and hematuria.

Findings:

  • The patient died 22 months after presentation.
  • Various treatments were administered, including hepatic arterial embolization, radiation therapy, chemotherapy, interferon-alpha, and somatostatin analogue.
  • Bone metastases showed a notable and prompt response to radiotherapy.

Implications:

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  • This case contributes to understanding the clinical behavior of pancreatic polypeptidioma.
  • It underscores the potential efficacy of radiotherapy for bone metastases in this rare tumor.
  • Further research is needed to establish optimal therapeutic strategies for pancreatic endocrine tumors.