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The use of animal models in cancer drug discovery and development

G A Curt1

  • 1National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Stem Cells (Dayton, Ohio)
|January 1, 1994
PubMed

Insights

Animal models are crucial for cancer drug discovery and development, aiding in pharmacology and toxicity assessments. Their use is expanding from early discovery to guiding clinical trials for new cancer therapies.

Area of Science:

  • Oncology
  • Pharmacology
  • Toxicology

Background:

  • Cancer drug discovery has shifted from broad screening to targeted approaches for adult solid tumors.
  • Animal models are indispensable for evaluating drug pharmacology and toxicity.
  • Preclinical data from animal models informs the design of early-phase human clinical trials.

Purpose of the Study:

  • To review the evolving role of animal models in cancer drug discovery and development.
  • To highlight the importance of animal models in preclinical and clinical research.

Main Methods:

  • Review of current literature on animal models in cancer research.
  • Discussion of the application of transgenic and SCID models for biological agents.

Main Results:

  • Animal models are integral throughout the cancer drug development pipeline.
  • Transgenic and SCID models offer unique advantages for biological agent development.
  • Animal models provide essential data for pharmacology, toxicity, and clinical trial design.

Conclusions:

  • Animal models remain vital for advancing cancer drug discovery and development.
  • Their application is expanding, particularly for targeted therapies and biological agents.
  • Continued use of animal models is essential for safe and effective cancer drug translation.

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