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HTLV-1 Tax: regulation of gene expression and disease
1Dept of Cellular and Molecular Biology, University of Tokyo, Japan.
Trends in Microbiology
|July 1, 1993
Abstract:
The human T cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes adult T cell leukemia and the neurological disorder tropical spastic paraparesis. Pathology apparently results from the activities of the Tax protein, which trans-activates the expression of viral and cellular genes by binding to various enhancer-binding proteins needed for transcription. This ultimately results in cell transformation, immortalization and disease.