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Related Experiment Videos

Human endogenous retroviral elements and autoimmunity: data and concepts

A Perl1, K Banki

  • 1Dept of Medicine, State University of New York, Health Science Center, Syracuse 13210.

Trends in Microbiology
|July 1, 1993
PubMed
Summary
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Inherited endogenous retroviral sequences (ERSs) are active in the human genome. Their aberrant expression and associated antibodies are linked to autoimmune disorders, potentially explaining familial links and antibody presence.

Area of Science:

  • Genomics
  • Immunology
  • Molecular Biology

Background:

  • The human genome harbors inherited endogenous retroviral sequences (ERSs).
  • Some ERSs are transcriptionally active and possess open reading frames.
  • Aberrant ERS expression and autoantibodies against ERS proteins are implicated in autoimmune diseases.

Purpose of the Study:

  • To investigate the role of endogenous retroviral sequences (ERSs) in autoimmune disorders.
  • To explore the connection between ERSs, familial aggregation, and antiretroviral antibodies in autoimmunity.

Main Methods:

  • Analysis of endogenous retroviral sequences (ERSs) in the human genome.
  • Detection of antibodies against ERS-encoded proteins in patients with autoimmune diseases.

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Main Results:

  • Identification of transcriptionally active ERSs with open reading frames.
  • Association of aberrant ERS expression and anti-ERS antibodies with autoimmune conditions.

Conclusions:

  • Endogenous retroviral sequences (ERSs) may play a significant role in the pathogenesis of autoimmune diseases.
  • ERS involvement could elucidate the familial clustering and presence of antiretroviral antibodies observed in autoimmune disorders.