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Hyperprolactinaemia and reproductive failure

M Gunaratne1

  • 1University of Peradeniya, Sri Lanka.

The Ceylon Medical Journal
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Hyperprolactinaemia, a condition of elevated prolactin, frequently causes infertility and menstrual disorders in women. Treatment with bromocriptine effectively restored reproductive function, leading to a 38.5% pregnancy rate.

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Area of Science:

  • Endocrinology
  • Reproductive Medicine

Background:

  • Hyperprolactinaemia is a common endocrine disorder.
  • It significantly impacts reproductive health in both women and men.

Purpose of the Study:

  • To investigate the clinical presentation and reproductive outcomes of hyperprolactinaemia.
  • To evaluate the efficacy of bromocriptine treatment in managing hyperprolactinaemia-related infertility.

Main Methods:

  • Retrospective analysis of 63 cases of hyperprolactinaemia (55 women, 8 men).
  • Clinical data including symptoms, hormonal levels, and treatment outcomes were reviewed.
  • Pregnancy rates and infant outcomes were documented post-bromocriptine treatment.

Main Results:

  • Infertility (74.6%) and menstrual disorders (27.6%) were the primary symptoms in women.

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  • Elevated luteinizing hormone (LH) levels were observed in 30.2% of cases.
  • Bromocriptine treatment resulted in a 38.5% pregnancy rate with 14 healthy births.

    • Conclusions:

    • Hyperprolactinaemia is a significant cause of infertility and menstrual dysfunction.
    • Bromocriptine is an effective treatment for restoring fertility in patients with hyperprolactinaemia.
    • Management of hyperprolactinaemia can lead to successful pregnancies and healthy offspring.