[Analysis of familial aggregation of lung cancer in Xuanwei]

Lung cancer aggregation was analyzed in relatives of the proband compared with those of his/her spouse in 370 nuclear families. Results showed the relatives of the proband had a greater risk of lung cancer compared with those of his/her spouse with an OR of 1.85 (P < 0.01). Even more, female relatives of the proband had much greater risk of lung cancer than those of his/her spouse with and OR of 2.64 (P < 0.01). It suggested relatives of the proband are more vulnerable to lung cancer than those of his/her spouse and genetic factor may contribute to pathogenesis of lung cancer.