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Pancreatic exocrine function and necrotising enterocolitis

C M Wood1, P MacKay, K D Willis

  • 1Academic Unit of Paediatrics and Child Health, University of Leeds, UK.

Early Human Development
|December 15, 1993
PubMed
Summary
This summary is machine-generated.

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Pancreatic protease deficiency is investigated as a cause of enteritis necroticans, a condition similar to necrotising enterocolitis (NEC). Studies found no significant difference in pancreatic exocrine function between infants who developed NEC and those who did not.

Area of Science:

  • Gastroenterology
  • Pediatric Medicine
  • Digestive Physiology

Background:

  • Enteritis necroticans shares clinical features with necrotising enterocolitis (NEC), a serious infant intestinal disease.
  • Pancreatic protease deficiency has been hypothesized as a potential etiological factor in enteritis necroticans.

Purpose of the Study:

  • To prospectively investigate pancreatic exocrine function in infants at risk for NEC.
  • To determine if pancreatic protease deficiency is associated with the development of NEC.

Main Methods:

  • Faecal chymotrypsin levels were measured to assess pancreatic exocrine function.
  • Infants identified as being at risk for NEC were prospectively studied.

Main Results:

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  • No significant difference in faecal chymotrypsin levels was observed between infants who later developed NEC and those who did not.
  • This suggests pancreatic exocrine function is not a differentiating factor in NEC development in this cohort.

    • Conclusions:

    • Pancreatic protease deficiency does not appear to be a significant etiological factor in the development of necrotising enterocolitis (NEC) in at-risk infants.
    • Further research may be needed to explore other potential causes of NEC.