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Global problems from exposure to asbestos

A L Frank1

  • 1Department of Preventive Medicine and Environmental Health, University of Kentucky, College of Medicine, Lexington 40536-0084.

Environmental Health Perspectives
|October 1, 1993
PubMed
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Asbestos exposure causes disease in all examined occupational groups, regardless of race or geography. Laboratory models help understand asbestos-related health effects and mechanistic changes, despite variable mutagenic activity findings.

Area of Science:

  • Environmental Health
  • Occupational Medicine
  • Toxicology

Background:

  • Human data on asbestos exposure health consequences are extensive.
  • Laboratory models, including animal and cellular studies, offer insights into asbestos-related health effects and mechanistic changes.
  • Asbestos, a group of six naturally occurring mineral fibers, has widespread historical use.

Purpose of the Study:

  • To review the health consequences of asbestos exposure.
  • To highlight the utility of laboratory models in understanding asbestos-related diseases.
  • To discuss the global impact and variability of asbestos-induced diseases.

Main Methods:

  • Review of human-derived data on asbestos exposure.
  • Analysis of laboratory models (animal and cellular studies) for asbestos-related health effects.

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  • Examination of epidemiological data on asbestos-induced diseases across populations.

    • Main Results:

    • Asbestos is a known carcinogen with documented disease across all examined occupational groups globally.
    • Asbestos-related diseases show no distinction based on race or geography.
    • Laboratory models provide mechanistic understanding, though asbestos exhibits variable mutagenic activity.

    Conclusions:

    • Asbestos exposure universally leads to disease in affected populations.
    • Laboratory studies are crucial for elucidating the mechanisms of asbestos toxicity.
    • Anticipated shifts in global commercial patterns may influence future asbestos disease patterns.