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Related Experiment Videos

Gene inactivation triggered by recognition between DNA repeats

J L Rossignol1, G Faugeron

  • 1Institut de Génétique et Microbiologie, CNRS URA 1354, Université Paris-Sud, Orsay, France.

Experientia
|March 15, 1994
PubMed
Summary
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Relationship between asymmetrical and symmetrical hybrid DNA formation during meiotic recombination.

Current genetics·2013
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Restoration to the parental genotype of mismatches formed in recombinant DNA heteroduplex.

Current genetics·2013
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Conversion in gene b1 of Ascobolus: Polarity of 6:2 and inverted polarity of aberrant 4:4 segregations.

Current genetics·2013
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[DNA repeats and homologous recombination: a probable role for DNA methylation in genome stability of eukaryotic cells].

Journal de la Societe de biologie·2000
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Diversity of homology-dependent gene silencing strategies in fungi.

Current opinion in microbiology·2000
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Histone H1 is dispensable for methylation-associated gene silencing in Ascobolus immersus and essential for long life span.

Molecular and cellular biology·1999

Gene inactivation in plants and fungi can occur due to repeated gene copies. This study explores Methylation Induced Premeiotically (MIP) and Repeat-Induced Point mutation (RIP) and their links to genetic recombination.

Area of Science:

  • Genetics
  • Molecular Biology
  • Epigenetics

Background:

  • Gene inactivation mechanisms in eukaryotes are crucial for genome stability.
  • The presence of repetitive DNA sequences can trigger specific genomic events.
  • Homologous DNA interactions play a role in various genetic processes.

Purpose of the Study:

  • To investigate gene inactivation linked to repeated gene copies in plants and fungi.
  • To explore the relationship between these inactivation phenomena and DNA-DNA interactions.
  • To discuss the connection between premeiotic processes and genetic recombination.

Main Methods:

  • Focus on phenomena of gene inactivation resulting from repeated gene copies.
  • Emphasis on Methylation Induced Premeiotically (MIP) in Ascobolus immersus.

Related Experiment Videos

  • Emphasis on Repeat-Induced Point mutation (RIP) in Neurospora crassa.

    • Main Results:

    • Gene inactivation is associated with the presence of repeated gene copies.
    • Methylation Induced Premeiotically (MIP) and Repeat-Induced Point mutation (RIP) are key premeiotic processes.
    • These processes are potentially linked to homologous DNA-DNA interactions.

    Conclusions:

    • Repeated gene copies can lead to gene inactivation in plants and fungi.
    • MIP and RIP are significant premeiotic mechanisms influencing genome integrity.
    • The interplay between these inactivation pathways and genetic recombination warrants further investigation.