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[Ileocolitis caused by Herpes simplex virus type 2]

E Leprince1, E Durous, Y François

  • 1Service d'Hépato-Gastroentérologie, Centre Hospitalier Lyon-Sud, Pierre-Bénite.

Gastroenterologie Clinique Et Biologique
|January 1, 1993
PubMed
Summary
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A severe acute colitis case was successfully treated after identifying herpes simplex virus type 2 (HSV-2) as the cause. Surgical intervention followed by antiviral therapy with aciclovir led to the patient's recovery.

Area of Science:

  • Gastroenterology
  • Virology
  • Infectious Diseases

Background:

  • Severe acute colitis presents a significant clinical challenge, often requiring surgical intervention when refractory to medical management.
  • Herpes simplex virus (HSV) infections are typically associated with mucocutaneous lesions, but systemic or atypical presentations can occur.

Observation:

  • A 51-year-old woman presented with severe acute colitis, necessitating a sub-total colectomy due to disease progression and lack of response to standard treatments.
  • Histopathological examination of the surgical specimen identified herpes simplex virus type 2 (HSV-2) as the causative agent of the colitis.

Findings:

  • The definitive diagnosis of HSV-2 colitis was established through analysis of the surgical specimen.
  • Post-operative treatment with the antiviral medication aciclovir resulted in complete resolution of the patient's condition.

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Implications:

  • This case highlights the importance of considering viral etiologies, specifically HSV-2, in severe acute colitis, even in the absence of typical herpetic symptoms.
  • Early diagnosis and targeted antiviral therapy can be crucial for managing severe, treatment-resistant colitis caused by HSV-2, potentially avoiding extensive surgical procedures or improving outcomes.
  • The findings underscore the utility of surgical specimen analysis in identifying unexpected pathogens contributing to severe gastrointestinal inflammation.